1. Niknejad H; Peirovi H; Jorjani M; Ahmadiani A; Ghanavi J; Seifalian AM "Properties of the amniotic  membrane for potential use in tissue engineering." Eur Cell Mater. (15). 01-JAN-2008. pp 88 - 99.
  2. Rahman I; Said DG; Maharajan VS; Dua HS "Amniotic membrane in ophthalmology: indications and  limitations." Eye. (23)10. 2009. pp 1954–1961.
  3. Baradaran-Rafii A; Aghayan H; Arjmand B; and Javadi M. "Amniotic Membrane Transplantation." Iran J Ophthalmic Res. (2)1. 2007. pp 58-75.
  4. John, T. "Human amniotic membrane transplantation: Past, present, and future.." Ophthal Clin N Am. (16). 2003. pp 43-65.
  5. Adly OA; Moghazy AM; Abbas AH; Ellabban AM; Ali OS; Mohamed BA "Assessment of amniotic and polyurethane membrane dressings in the treatment of burns." Burns - 01-AUG-2010; 36(5): 703-10.
  6. Huiren Tao & Hongbin Fan "Implantation of amniotic membrane to reduce postlaminectomy epidural adhesions." Eur Spine J - 01-AUG-2009; 18(8): 1202-12. (). 2009.
  7. Arora R; Mehta D; Jain V "Amniotic membrane transplantation in acute chemical burns." Eye (Lond). (19)3. 01-MAR-2005. pp 273-8. 
  8. Kay H; Nelson D; Wang Y. “The Placenta: From Development to Disease.” Wiley-Blackwell. 2011.

Mimedx Studies

  1. "Biological Properties of Dehydrated Human Amnion/Chorion Grafts: Implications for Chronic Wound Healing" ​ Koob T, et al
    Read the entire study here
  2. "A prospective randomized comparative parallel study of amniotic membrane wound graft in the management of diabetic foot ulcers" Charles Zelen, DPM, FACFAS, FACFAOM, et al
    Read the entire study here
  3. "An evaluation of dehydrated human amniotic membrane allografts in patients with DFUs" ​ Charles Zelen, DPM, FACFAS, FACFAOM ​
    ​Read the entire study here

The PURION® Process

Although this technique may seem new the Human amniotic membrane allografts have been utilized in various forms of reconstructive surgeries since early 1900s. The Interest in amniotic membrane use went on a decline in the early 1980’s due to transmittable diseases such as HIV/AIDS, Hepatitis, etc. Reintroducing its popularity in late 1990s to 2000s amnion was used in treatments of ophthalmic wounds with cryopreserved amniotic tissue. In 2007 the PURION® Process was developed by a Surgical Biologics company called MiMedx®. After the Purion process developed the utilization of amniotic membrane as an allograft accelerated and allowed for dehydrated and sterilized of the tissue. The easy to use graft is able to be kept at room temperature and maintain a 5 year shelf life. Since release the application has been used in surgical settings and have no adverse events associated within various fields and applications. To date 130,000 allografts have been released for human implantation in various surgical applications, such as orthopedics, gynecology, trauma, and burn units. With the 130,000 dispensed grafts there has been no reported adverse events associated with the tissue graft.

Certified tissue banking center approved by

Relative amount of indicated growth factor determined by ELISA Assay

PGF-AA      +++++
bFGF          ++
TGF-b1       ++
EGF            +

The Amniotic membrane is a very particular material and an enriched source of the following:

  • Collagen types I, III, IV, V, and VII
  • Extracellular matrix (ECM), which contains specialized proteins fibronectin, laminins, proteoglycans and glycosaminoglycans
  • Growth factors such as epidermal growth factor (EGF), transforming growth factor beta (TGF-b), fibroblast growth factor (FGF), and platelet derived growth factor (PDGF).
  • Natural

  • Speeds recovery

  • Reduces inflammation

  • Enhances healing

Amniotic Membrane Description

The Placenta is composed of various layers and rich biologic sources. The innermost layer of the placenta being the amniotic membrane layer. The amniotic membrane is a collaborative structure of layers which include a lining of epithelial cells, a basement membrane and an avascular connective tissue matrix. The components of the placenta are complex system of biologic structures that possess vast physiologic characteristics, these characteristics can alter in the level of importance during each stage of gestation.  The function of the Placenta, during pregnancy, is to allow the passage of nutrients, metabolites, hormones for development and metabolic gases. The exchanges provide physical and immunological protection to the developing fetus.

  • No immune response

  • Reduces scar tissue formation

"Micronized amniotic membrane allograft"

Aminofix Sports Med